Tyler Warren Ruled Out Against Titans, Leaving Colts Offense Searching for Answers

Adam Schefter dropped the hammer on Sunday morning: Indianapolis Colts tight end Tyler Warren is officially inactive against the Tennessee Titans. If you were holding out hope for a miraculous pregame recovery, it is time to pivot.

Warren went down with a groin injury during an 11-on-11 drill in Friday's practice, which is the exact kind of late-week downgrade that sends fantasy managers into a blind panic. Trying to find a viable tight end on the waiver wire at 11 a.m. on a Sunday is like trying to buy a decent Valentine's Day gift at a gas station.

"Adam Schefter tweeted: 'Colts TE Tyler Warren is inactive today.'"

The Colts desperately need a bounce-back game after getting completely outclassed by the Pittsburgh Steelers 34-22 last week. Losing Warren does not make that assignment any easier. The 6-foot-6, 256-pound tight end has already hauled in 30 receptions for 213 yards and two touchdowns this season, proving his 2025 Pro Bowl rookie campaign was not a fluke.

Quarterback Daniel Jones has leaned heavily on Warren as his primary safety blanket. Without that massive target over the middle, the entire geometry of the Indianapolis offense changes. Anyone holding Colts passing props or looking at the over/under for this AFC South matchup has to factor in just how much this offense stalls when Jones is forced to look elsewhere on third down.

Early reports suggest Warren is dealing with a Grade 1 strain and should only miss about a week. That is a massive sigh of relief for a franchise that views him as a foundational piece. For now, the Colts just have to survive the Titans without him, and bettors will have to wait until Wednesday's practice report to see if he has a shot at suiting up for Week 7.